Hair Loss: Steroid Hormones

Researchers have devised to control the production of steroid hormones, but only at the local level (the skin). The solution is to find a substance capable of blocking the action of 2 enzymes: the 5a – reductase and aromatase.

To try to find a solution to this health issue, Dr. Heinrich Wieland, a chemist, and Alfred Schmidt, a pharmacologist, began in 1985 to test various substances.

After several years of research and many laboratory experiments, they concluded that a phytosterol complex with ß-sitosterol as the primary substance could become a very active and at the same time completely harmless to the inhibition of sex steroid hormones locally in the skin.

This complex of phytosterols has the following properties:

1. it is hydrophobic, so it can be easily absorbed through the skin

2. it inhibits the activity of the enzyme 5a-reductase and aromatase.

3. it is non-toxic and hypoallergenic.

Hair Loss Explained in Science

 

It was long thought that androgenetic alopecia was linked to an overproduction of testosterone. That is why we assigned to a bald manhood over the average.

We know now that this is wrong: it is not a production of testosterone than average, but increased sensitivity of hair follicles to male hormones.

The disorder is not a hormonal disorder but an abnormal function in the skin of the scalp, causing hair loss.

The androgenic alopecia is the most common form of alopecia, it affects men but also women. It is the gradual decrease in the quality and quantity of hair, hormonal and hereditary origin.

ANDRO: hair loss comes from an abnormal reaction hair androgen (male hormones that are present also in women).

GENETIC This abnormal reaction is linked to genetic predisposition. The androgenic alopecia is excessive sensitivity of hair follicles to male hormones due to heredity, both for women than for men. It is not a hormonal disorder but a local function abnormally in the skin of the scalp that causes hair loss.

Understanding the Reason for Hair Loss

 

Spurred on by the enzyme 5alpha-reductase (an enzyme located in the scalp) DHT (a hormone local) will stimulate the sebaceous glands. They are increasing their oil production will stagnate in the hair follicle, the block gradually suffocate the bulb and cause hair loss.

DHT also shortens the life cycle of the hair: stimulated by androgens, the life cycle of the hair only lasts more that 1 to 2 years (instead of approximately 4 years, hopefully).

Result: the hair fall weakened before reaching their maximum length. Each new hair is growing late, his life is shortened: the gradual evolution toward baldness. Stress also has a real impact on hair loss and is a factor that triggers or exacerbates alopecia and hair loss.

Food and Hair Loss?

 

All men are threatened by baldness … And women are not spared. Can we treat her hair and the fight against hair loss range of a sudden? To find out, we interviewed Dr. Richard Aziza, aesthetic plastic surgeon and specialist in the scalp and author of “Hair loss, what solutions.” According to him, a healthy lifestyle is important … but not enough.

Doctissimo: The power allows it to keep her hair healthy?

Dr. Aziza: Hair is a reflection of how we live! When we’re stressed, tired, sick, this has an impact on our hair. It becomes dull, brittle, and so on. And our food is a factor that affects our hair. Balanced eating is important to bring the roots all the elements necessary for the manufacture of hair, to preserve this great flexibility and vitality touted by advertisers. The hair of essential food, the protein-rich sulfur amino acids (meat, fish ….) And vitamins B and PP for example.

Doctissimo And all shampoos that promise to “feed” the hair, are they effective?

Dr Aziz: As far as I know, cosmetics do not cross the skin barrier … But this is not what shampoos are unnecessary. Because each hair has a sebaceous gland. Or shampoo for the treatment of hyper or hyposécrétions that make the hair too fat or too dry. And they can give volume, thanks to their electrostatic properties. And contrary to popular belief, wash their hair often does not promote hair loss.

Doctissimo: At this point, is this a good diet can reduce hair loss?

Dr Aziz: It is important to eat varied, making sure to provide hair with the nutrients they need. If deficiencies can threaten the health of the hair, by contrast, the excess can be harmful. Thus, people who are too fat diet and those who suffer from high cholesterol are threatened with loss of hair. And paradoxically, some medicines to fight against high cholesterol levels can, by their side effects, also promote the fall …

But we must be aware that hair loss is genetically programmed: diet can prevent!

Causes of Hair Loss

 

Hair fall (45 to 60 per day) and renewed permanently. The normal hair loss is predominant in the late summer and spring. Hair loss hair above 60 per day is considered excessive.

The causes of hair loss are numerous.

Among the diffuse hair loss, the most common are the common hair loss (androgenic alopecia, male and female) and telogen effluvium (after a high fever, pregnancy, a drug or a severe). The anagen effluvium leads about him a sudden hair loss after chemotherapy or during the pelade. The genetic hair loss occur at birth or rather in childhood (moniletrix syndrome anagen hair falling, ectodermal dysplasia).

The hair loss can be found in localized part of the male androgenic alopecia (gulfs, tonsure), infections by fungi (ringworm) of pelade plate, induced by the alopécies ups (trichotillomania, braids and hair) or cicatricial alopecia (lupus erythematosus, lichen, folliculitis décalvante, central centrifugal scarring alopecia, alopecia frontal fibrosing post-menopausal …). Tumors and skin growths also accompanied a localized hair loss (Sebaceous hamartoma, basal cell carcinoma, squamous cell carcinoma).

The responsibility of stress has often been the cause of hair loss but has not previously been confirmed by scientific studies. However, we are all victims of stress induced by the events of everyday life, we must consider the role of stress when hair loss occurs in the weeks following an emotion with an intensity abnormally high.

The effective treatment of hair loss needs to determine the cause.

• The telogenes effluvium may indicate support for a deficiency (iron, vitamin B12) or a thyroid problem but they usually recover without treatment after 3 to 4 months (after pregnancy, fever, surgery ect …). The Effluvium telogenes induced by a drug (isotretinoin anticholesterol, anticoagulant …) require whenever possible replacement therapy with another drug.

• The anagen effluvium chemotherapy may to some extent, be minimized through prevention (helmet refrigerant).

• The skin and the general conditions which cause hair loss should receive specific treatment tailored to the specific case. Ringworm requires an antifungal treatment by systemically. Treatment of lichen uses corticotherapy local or general Intralesional and sometimes synthetic antimalarial (Plaquenil). The cicatricial alopecia treatment are difficult, they require the use of an expert from the scalp. Once the reconstruction process stabilized by hair transplant is sometimes an option.

• The congenital alopécies may benefit from a hair restoration by transplantation of hair or hair of an addition.

• The pelade small plates often heal quickly without treatment but may recur while pelades largest involving rapid that uses local corticosteroid (lotion), intralesional (injections in the scalp) or rarely corticotherapy General. The puvathérapie the dioxyanthranol and application of a sensitizing substance (diphencyprone) treatments are often recommended.

Science of Hair Loss

 

Spurred on by the enzyme 5alpha-reductase (an enzyme located in the scalp) DHT (a hormone local) will stimulate the sebaceous glands. They are increasing their oil production will stagnate in the hair follicle, the block gradually suffocate the bulb and cause hair loss.

DHT also shortens the life cycle of the hair: stimulated by androgens, the life cycle of the hair only lasts more that 1 to 2 years (instead of approximately 4 years, hopefully).

Result: the hair fall weakened before reaching their maximum length. Each new hair is growing late, his life is shortened: the gradual evolution toward baldness. Stress also has a real impact on hair loss and is a factor that triggers or exacerbates alopecia and hair loss.

The androgenic alopecia top of the skull and forehead is in men and women, but mainly affects men. Age of onset varies. It is often hereditary.
The diffuse alopecia on the entire scalp is predominantly female.
In children have included the Trichotillomania (he pulls himself hair, often in secret), the total rare pelade décalvante and ringworm Tønder (but in this case it is limited plaques with crusts and suppuration )

How to know if the fall is abnormal?

For a tensile test, hair unwashed for 3 days, on 10 it would pull hair over 2.

Causes:

-Many medications can be involved:
chemotherapy, anticoagulants, androgens (among other things contained in the anabolic) androgenic progestins, lithium, antidepressants, neuroleptics, antiepileptics, antialdostérone, antithyroid synthetic derivatives of cortisone
-Some deficiencies:
iron deficiency (pregnancy, lactation, chronic bleeding, etc …)
malnutrition or undernutrition (backgrounds, diets, anorexia nervosa)
-Some endocrine diseases:
Front row: hypothyroidism and hyperthyroidism
Much more rarely hypopituitarism or hyperprolactinemia (disturbances in the pituitary gland)
excess androgens (hormones masculinisantes) absolute or relative (menopause)

Treatment

* If one of the reasons cited above is found, on trafficking.
* Avoid abuse hair: braids, perms, brushing.
* Among women, where contraceptive use a non-androgenic progestin (desogestrel / ethinylestradiol)
* Fight against seborrhea (oily hair with dandruff and itching) with suitable shampoo, antifungal, shampoo oil Cade (film)
* Minoxidil:
This product is available in lotion under several different brands (Alostil, Regain)
As an anecdote, it was used as a tablet anti-hypertensive.
Lotion 2%, apply morning and evening for several months (except pregnancy, lactation). In case of failure after 4 months in humans, then go to Alostil 5%.
The beneficial effect of Minoxidil cease as soon as treatment is stopped. The product is not reimbursed, it is a real financial investment, and like any medication not reimbursed, the price is free so compare prices! !
* Promestriéne solution, local application, suitable for both sexes.
* Propecia: only in humans, 1comprimé per day for at least 6 months. Not reimbursed
* Solution ultimate micrografts hair collected in a dense area.
Not reimbursed and expensive.

Hair Starting to Fall off?

 

The scalp hair is approximately numbered at 100,000. Each hair has a particular structure and is anchored in the scalp hair. The hair is a cycle of life that may vary from one hair to another and from one individual to another.

Lifecycle hair: in the early years (2 to 6 years) the hair grows about 1 cm per month, this phase is called phase of growth, then a phase of transformation, which leaves room next to the hair intervient and a resting phase during which separates the hair on the scalp and ending the life of a human hair.
That is why a healthy scalp a person naturally loses on average 40 (sometimes less) to 100 hairs per day.

Hence we talk about hair loss when a man loses over 100 hairs per day and over a long period (months).

A simple way to get the number of hair you lose per day is counted, for example, the morning after your shower on the ground after passing the comb, the number you find on your clothes and your bed (Hint: Choose white sheets to better distinguish them).

If you reach more than 100 hairs per day and lost it over several weeks then it should start, if you have a problem aesthetic or psychological (since losing his hair does not pose a medical problem itself), to inform you on treatments available to stem this loss.

Natural Hair Loss Treatments

 

In some cases, the use of herbal remedies used by grandmothers may be useful against hair loss.

In some cases, the use of herbal remedies used by grandmothers may be useful against hair loss.

Generally the drugs (classical) appear to be more effective than natural treatments.

Green tea, for use primarily in the form of herbal tea (according to some studies the consumption of green tea could reduce hair loss, no study has clearly come to prove its effectiveness or not).

Germinated wheat, used mainly in the form of wheat germ. Effective against hair loss, if only due to a deficiency of certain nutrients (if rare).

Millet, to be generally in the form of capsule (capsule).

The male androgenic alopecia benefits of treatment with finasteride (Propecia ®) and minoxidil 5%, dutasteride is being tested in this indication but the results are preliminary. Hair transplants are the only way to retrieve natural hair, the current techniques for follicular grafts give excellent results when performed by expert teams. The female androgenic alopecia is common, are used in treatment of 2% minoxidil and antiandrogens (cyproterone acetate) a hyperandrogénie is clear; finasteride is not indicated in women but being evaluated in the postmenopausal women.

Why Do We Lose Hair Every Day?

 

It is normal to lose 50 to 150 hairs per day. The amount of hair loss depends on several factors: the total number of hair, a healthy person and the average growth cycle of hair. Hair damaged or broken increase the apparent number of lost hair.

Responsible for hair loss
Some conditions such as severe disease, surgery, anorexia or bulimia, pregnancy, childbirth, menopause, anemia, intense emotional stress, a serious infection, injury, certain medications or a severe diet lead to hair loss. Hence, a few months later, several hair fall at the same time, giving a much less hair provided. This type of hair loss is reversible and does not baldness. In addition, other reasons such as diseases of the scalp or hair themselves may also be involved.

The growth cycle of hair
Growth fluctuated slightly with the seasons. It is more active in summer and winter. The hair grows a little faster when it is new and slow towards the end of its growth phase. It grows less quickly as you age. Each follicle has its own genetic program, which means that the loss may be faster in some than in others. The average growth phase of a hair follicle is about four years. At the end of the growth phase, the follicle enters a resting phase and frees the hair that falls next. The follicle rests for about 12 weeks and then start the program with a new hair. And it continues throughout life.

Age can determine the hair loss?
The hair loss may start at age 18 or after 40. Have abundant hair until the age of 40 years does not mean that they never fall. There is no definitive age where we can say that they never lose his hair. Therefore, any treatment must be tailored to each individual case.

Stress and diet
The stress and a strict diet can cause temporary loss of hair, but once the problem corrected, they grow normally. Some products containing amino acids, claim help follicles to produce more hair. These products are not significant difference in people with a balanced diet. In addition, biotin (vitamin B8) and folic acid, for growth of hair, are also part of any balanced diet. We must not forget that excessive doses can lead to further loss of hair. A multivitamin supplement with a balanced diet is more than sufficient to meet the needs of hair.

Inadequate care can cause hair loss?
The hair loss is not caused by inadequate maintenance of hair. Neither the scalp massage or brushing or drying the towel does have proven effective in stopping hair loss. The frequency of shampoo would not affect this problem.

Shampoos and medicines
It is wary of any product guarantee immediate results. Because regardless of the treatment, it will operate according to the growth of hair. All these products must be used faithfully for several months before giving the results. The hair loss is a slow process and it is also true when trying to stop their fall.

Your doctor may prescribe Rogaine ®, a topical solution is applied to the scalp can stop the majority of hair loss, and in some cases to get a slight regrowth. Suitable for common baldness in men, Propecia ®, a prescription medication,
can stimulate hair growth. The effects of the drug are generally after three months of treatment. The effectiveness of the drug varies: in most cases, hair loss ever and there is regrowth, which will never complete. In addition, these new hair will fall in the year after stopping treatment.